Known during his lifetime as one of the most financially successful individuals in the world, Hughes insisted on using tissues to pick up objects to insulate himself from germs.
The creator and star of the children's cartoon Bobby's World and host of the NBC game show Deal or No Deal, Mandel's anxiety affects him to the point that he does not shake hands with anyone unless he is wearing latex gloves.
One of the highest paid comedians ever, Jerry Seinfeld is a self confessed germaphobe. Even his character played on the show is obsessed with keeping things clean.
Another Howard?! How is this possible. Apparently people with the name "Howard" are more likely to be germaphobic. Case closed.